Abstract Background Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family Ceramic Ornament Gift Box protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis.MCL1 is a fast-turnover protein that is degraded via an ubiquitination/proteasome-dependent mechanism.Although several E3 ligases have bee
BackgroundAntibody-mediated rejection (ABMR) is a major cause of graft loss in kidney transplantation, often associated with de novo donor-specific antibodies (dnDSA).The detection of clinically relevant dnDSA relies on evaluating reactivity in single antigen bead (SAB) assays.Immunogenetic mismatches between donor and recipient, particularly invol
Aegicetus gehennae is a new African protocetid whale based on a partial skull with much of an associated postcranial skeleton.The type specimen, Egyptian Geological Museum, Cairo [CGM] 60584, was found near the base of the early-Priabonian-age (earliest late Eocene) Gehannam Formation of the Wadi Al Hitan World Heritage Site in Egypt.The cranium is
Brenna Bath, Stacey Lovo Grona School of Physical Therapy, College of Medicine, University of Card Upsell Saskatchewan, Saskatoon, SK, Canada Background: A spinal triage assessment service may impact a wide range of patient outcomes.Investigating potential predictors of success or improvement may reveal why some people improve and some do not, as w